GI · CMS status A
45381
Colonoscopy with submucosal injection
Colonoscopy, flexible; with directed submucosal injection.
Work RVU
4.42
2026 Medicare pays
$327.33
National GPCI · non-facility · CF $33.4009
RVU anatomyWork 4.42 + Practice 4.85 + Malpractice 0.53 = 9.80 total
Work (your effort)Practice expenseMalpractice
Billing guidance for 45381 is locked
- When to use it: the exact clinical situations that support billing 45381
- Documentation checklist: the 3 elements your note needs before submitting
- Common pitfalls: the 1 mistakes that get 45381 downcoded or denied
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Common modifiers
59
Common ICD-10 pairings
K63.5
Pairs well with
Educational reference, not billing or legal advice. Verify against your payer contracts and your compliance team before submission.