GI · CMS status A
45381
Colonoscopy with submucosal injection
Colonoscopy, flexible; with directed submucosal injection.
Work RVU
4.42
2026 Medicare pays
$327.33
National GPCI · non-facility · CF $33.4009
RVU anatomyWork 4.42 + Practice 4.85 + Malpractice 0.53 = 9.80 total
Work (your effort)Practice expenseMalpractice
When to use it
Submucosal injection (e.g.
Full guidance
saline lift before resection, India ink tattoo).
Documentation checklist
- ✓Lesion location.
- ✓Injection agent and volume.
- ✓Purpose (tattoo, lift).
Common pitfalls
- !If polypectomy also performed, bill the polypectomy code with 45381 added if appropriate per NCCI.
Common modifiers
59
Common ICD-10 pairings
K63.5
Pairs well with
Educational reference, not billing or legal advice. Verify against your payer contracts and your compliance team before submission.