GI · CMS status A
45380
Colonoscopy w/ biopsy
Colonoscopy, flexible; with biopsy, single or multiple.
Work RVU
3.91
2026 Medicare pays
$326.99
National GPCI · non-facility · CF $33.4009
RVU anatomyWork 3.91 + Practice 5.49 + Malpractice 0.39 = 9.79 total
Work (your effort)Practice expenseMalpractice
When to use it
Diagnostic colonoscopy with biopsy (no polypectomy by snare).
Documentation checklist
- ✓Biopsy site(s) and reason.
- ✓Number of specimens.
- ✓Same documentation as 45378 plus biopsy detail.
Common pitfalls
- !If polyp removed by snare, use 45385 instead; if removed by hot biopsy/cold biopsy techniques, bill the appropriate code.
Common modifiers
PT33
Common ICD-10 pairings
K63.5K51.90
Educational reference, not billing or legal advice. Verify against your payer contracts and your compliance team before submission.